TRANG CHỦ Sản phẩm Parr Multiple Reactor System Combinatorial Chemistry & High-Throughput Screening

Combinatorial Chemistry and High-Throughput Screening shifts compound design from a one molecule at a time approach to a rapid and often automated parallel synthesis of a focused set of compounds. Parr Instrument Company offers many strategies to this rapidly growing methodology.






























Three Reactor Parallel System


This system incorporates three 1.8 L 4570 Series High Pressure/ High Temperature reactors rated for use at 5000 psi (345 bar) @ 500 °C. The reactors in this system are manufactured of Alloy C-276 and are equipped with internal coupon holders to facilitate study of corrosion processes in harsh environments. This application does not require precisely controlled gas delivery; hence individual gas feed vessels are not present, though gas supply and gas vent manifolds are provided. A 4871 Process Controller is also included (not shown).
















Four Reactor Parallel System


This system consists of three 160 mL and one 450 mL 4560 Series Reactors rated for use at 3000 psi (200 bar) @ 350 °C. This configuration allows both high throughput screening and scale-up, if desired. Gas supply and vent manifolds for the entire system and pressure control for the larger reactor are provided. Reactor temperatures and stirring speed are controlled by four 4848 Reactor controllers (not shown).















Five Reactor Parallel System


This Parallel Reactor System incorporates five 160 mL, 4560 Series Stirred Mini Reactors rated for use at 350 °C and 3000 psig / 200 bar. Each of the reactors has a dedicated high pressure (5000 psig / 345 bar) 100 mL general purpose vessel associated with it serving as a reactant gas feed reservoir. These feed vessels are located above and immediately behind the main reactors and are each equipped with a dedicated pressure transducer, thermocouple and a constant pressure regulator. The regulator maintains the downstream reactor at a constant pressure while the pressure transducer/thermocouple combination allows the process controller to accurately monitor and record the real-time consumption of reactant gas.

This system would normally be used to study various aspects of hydrogenation or carbonylation reactions. The 4871 Process Controller also controls and records the reactor temperature, stirring speed and monitors the reaction pressure. The compact reactor system stand incorporates not only reactant gas feed and vent/ purge manifolds but cooling water feed and drain manifolds to simplify the installation and hook up.











Six Reactor Parallel System with Automatic Sampling System


This system includes six 25 mL, 4590 Series Stirred Micro Reactors rated for use up to 3000psi (200 bar) @ 350 °C. Gas supply and vent manifolds are provided, as well as manifolds to deliver and drain cooling water to/from either the internal cold finger or the external aluminum block heaters with cooling channels.

Note the automated liquid sampling system present on the reactor on the left. This sampling system allows the sequential collection of several ~1 mL liquid samples under full reactor operating pressure, and automatically clears the liquid sampling lines between samples. Control is provided by a 4871 Process Controller.












12 Station High Pressure Compact Lab Reactor System


This system makes use of the lower cost 5500 High Pressure Compact Lab Reactors that feature a modified stand, aluminum block heaters, removable vessels and a standard gage block assembly. A control system (not pictured) automates the process, monitors the parameters and collects the data.













16 Station Multiple Reactor System


This system is a combination of sixteen standard 4560 Mini Reactors with heaters, valves, pressure gages and rupture disc assemblies and two 4871 Process Controllers with sixteen 4875 Power Controllers. It allows the user to run multiple reactions simultaneously, applying the principles of high-throughput experimentation. Individual variables that can be controlled are gas mixtures, liquids, catalysts or other solids, stirring speed, temperature, pressure and time.